How to Optimize Fertility | Dr. Andrew Huberman | The Tim Ferriss Show

16 April 2025


How to Optimize Fertility | Dr. Andrew Huberman | The Tim Ferriss Show



Brought to you by Athletic Greens’s AG1 all-in-one nutritional supplement http://athleticgreens.com/tim, Eight Sleep’s Pod Cover sleeping solution for dynamic cooling and heating http://eightsleep.com/Tim, and Protekt’s REST sleep supplement https://protekt.com/tim

Resources from this episode: https://tim.blog/2023/03/08/dr-andrew-huberman/

cc: @hubermanlab

Andrew Huberman, PhD (@hubermanlab), is a neuroscientist and tenured professor in the Department of Neurobiology at Stanford University’s School of Medicine. He has made numerous important contributions to the fields of brain development, brain function, and neural plasticity. Work from the Huberman Laboratory at Stanford Medicine has been consistently published in top journals including Nature, Science, and Cell.

Andrew is the host of the podcast Huberman Lab, which is often ranked as one of the top five podcasts in the world by both Apple and Spotify. The show aims to help viewers and listeners improve their health with science and science-based tools. New episodes air every Monday on YouTube and all podcast platforms.

Please enjoy!

Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running.

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foreign if you're 42 years old or younger you can freeze eggs might meet someone later and decide you want to conceive children or use a donor after 42 I think it's at 42 and a half you can only create embryos and freeze those they're just not the eggs are on average are just too aged out males if you want to be a sperm donor you know ideally you're going to do that before 45 sperm donor or you might want to do IVF someday now there is a significant increase in the incidence of autism with each half decade for the father you know so as you go from you know 30 to 35 to 40. the sperm age matters but the increases still incredibly small overall so it's not something you can really point to and say oh it's the sperm you know or it's the egg for that matter okay now do's and don'ts we can now easily look back to the beginning of our discussion it's very clear that quality sleep on a regular basis sunlight keeping stress in check healthy relationships over all of that is going to support sperm health and egg health no question about that it's also clear that getting sufficient omega-3 fatty acids is going to support sperm health and neck Health I'll just point out that if there were One supplement that really seems to move the needle in terms of egg quality which is a morphological but also a meaningful physiological metric or and sperm quality which is going to be shape motility you don't want what are called Dead sperm they're always going to be some in a sample because of the age of the sperm Etc and the way the spermatogens the cycle go but you want forwardly motile sperm the other ones are called twitchers so you know they just Twitch in place they can actually take twitchers and force them into the egg during IVF something called ixy but in general the greater number of forward motile sperm I'm swimming them towards India yeah yeah I'm actually swimming them an angle away from Tim so forward on our first person podcast exactly can be greatly increased by supplementation with L-Carnitine so egg health and sperm Health greatly enhanced by L-Carnitine pretty remarkable results there injectable L-Carnitine of about one mil one Mig per day okay that has to be prescribed by a doctor and that's I am that's intramuscular yeah or oral capsules are available over the counter then you have to get up to four or five grams per day wow yeah and that could increase tmao and some other markers that aren't great for cardiovascular health because of the way it's processed by the gut but you can offset that by taking 600 milligrams of garlic because of the allicin and garlic okay smoking cigarettes vaping cigarettes really good for sperm terrible for sperm terrible for eggs smoking cannabis vaping cannabis also terrible eggs and sperm people don't like to hear that 15 of women I can't believe the statistic but I've seen it over and over and to check my eyes but 15 ingest cannabis at some point during pregnancy 15 probably not a good idea now a lot of people say oh I smoke weed every day and got my wife pregnant you never know how healthy your children would have been you never you just never know I'm not saying your children are unhealthy but you never are also going to be there will always be edge cases where like I smoke crack every week and never slept for 14 days straight my kids are great and you're like okay just because you happen to be the one mutant right right right yeah if you want to optimize for who can thread that needle exactly it doesn't mean you're a good model exactly so L-Carnitine can really help avoid smoking anything you know the issue of tinctures and Edibles is a different subject altogether I think the big wow for me was something again I'm just gonna tip my hat to you which is that in 2015 I taught a class at I was in a professor at UC San Diego on neural circuits and health and disease and I decided to do a lecture on whether or not cell phones inhibit sperm health and or testosterone level the data were very mixed frankly there were essentially two good studies in rats each of them taking a standard smartphone putting it under a rat's cage and then looking at some metrics related to testicular Health sperm Health Etc one showed increases in testosterone the other show decreases so it was kind of a disappointing situation so I would present both now there is an extensive meta-analysis I can send you this for the for the show notes if you like an extensive meta-analysis of dozens of studies I'll add it to the next reprint for our body and it very convincingly shows that keeping the cell phone in one's pocket so this isn't putting it to your head this isn't putting on the desk in front of you but keeping it on and in one's pocket and it does not matter if it's on Wi-Fi or you're using seller decreases sperm quality which means forward motility number of healthy sperm per ejaculate Etc even ejaculate volume to some extent and lowers testosterone overall which is perhaps not surprising giving the known heat effects of the phone so even though it doesn't feel hot to the touch there are heat effects sperm don't like heat in fact the most promising male contraceptive that's out there that's not a condom is a it's like a cuff that goes around the vas deferens which is the portal from the testes to the urethra that allows the ejaculate to leave the body that heats that right I mean asano will it's not a great form of contraception because it's not sure proof but it will reduce your total number of motels born by 75 or so when I go in the sauna because when I do hope to concede children somewhere so I wear shorts into the sauna and I actually put a a cold pack at my groin yeah while I'm in there it's actually when the sun is really hot it's also it makes it a little less unpleasant it's a little painful but you definitely don't want to do that on bare skin I'm chuckling too but heat is part of the problem with the cell phone but it turns out yes and here people are gonna think I'm a crazy person but they might think that already the emfs that business is real yeah now is it so real that it's giving us gliomas unclear I'm not gonna go there the data aren't in but it is very clear that the radiation from phones the emfs and the heat are combining to reduce sperm quality motility and overall testosterone so it's a simple thing turn off your phone completely or even better just don't put it in your front pocket if you have to put in a pocket but in your back pocket if you even better would be to put it in a shoulder pocket or a backpack and I also I'm a weirdo perhaps but I don't like keeping the phone to the my head too long but that's also because I don't like holding onto my Edge for too long we don't know very much about the effects of EMS and heat effects on the different tissues of the body but we now know a lot about the effects of heat and emfs on sperm quality and it's not a good picture for the sperm where does airplane mode fit into this equation if at all in terms of between on and off I mean does it prevent or mitigate some of the effects it seems to yeah it seems to here's what's really scary about this meta-analysis their conclusion is that the total amount of time spent with the phone in the pocket is not a strong determinant that it's it's not all or none but that the threshold Beyond which you start seeing these damaging effects is pretty low so you know again here we're talking about a don't not a do and so it's pretty straightforward you know don't keep the phone in your front pocket if you're concerned with sperm health and testosterone production now why is sperm health and testosterone production so correlated and you say well duh it's because you know testosterone and sperm but if you're not interested in conceiving children you might not think this is an issue but remember that the two types of cells those lidic cells and the sertoli cells of the of the testes combine testosterone in the Androgen binding protein to give rise to sperm so anytime you're seeing a reduction in sperm you are definitely seeing that as a reflection of reduction in Androgen binding protein which means whatever testosterone you have around is also not having the effect on that local organ that it should in other words the testes and the ovaries are very interesting organs because they secrete hormones into the body to go have effects but they also have effects on themselves and it's self-amplify yeah and so this just seems like such a straightforward one to me and you said this back in when was the four hour body published came out in 2010 yeah yeah and I remember you and poliquin and a few other people saying like don't keep the phone in your pocket and I remember lecturing to about 400 students about this and I would say about half just you know by my read about half of the the guys in the class took the phone out of their pocket when they heard this I think young people who aren't thinking about having children at all right now are absolutely the ones that should be most concerned yeah yeah it is true you can as they told us in high school it just takes one sperm but you know just takes one sperm but in order to get that one sperm to the egg in Vivo you know not IVF but it's called natural conception there's a lot of territory that needs to be covered there's a lot of chemical environments that need to be dealt with you want the healthiest sperm so I would say also having gone through this process with an X to create embryos even though you can say it only takes one sperm in IVF as well you want to Stack the odds in your favor which means you need good morphology good motility and you need a good count of non-crippled sperm yeah sperm analysis can be a humbling thing because you know no matter what no one's getting 100 motile forward limo tile everyone males and females learn a lot about their biology what they're doing well what they're doing less well when going down that pathway of IVF I think I think for women one of the big surprises is that it doesn't take much ingestion of alcohol to diminish egg quality you know Beyond two or three drinks per week per week you really start to see reductions inequality that are probably indirect through effects on diminished sleep and changes in stress hormones and so you know again some people will be more resilient to this than others people always like to make jokes about how alcohol facilitates the conception process you know Etc you know I think that in general you know if women are having very regular Cycles whether or not they're 28 days long or 35 days long is less important perhaps and maybe fairly regular women in general tend to know more about their bodies and because they cycle than than men but I if I could go back in time to my 30s I sure sure would have Bank sperm then yeah and you know I feel good about where I've gotten my parameters but it's really interesting as you learn this you just realize that freezing sperm freezing eggs is a great idea and freezing embryos makes sense if you have the appropriate pairing or situation right yeah and that life gets so much easier for those wishing to conceive when you have healthy embryos Frozen in the bank yeah anyway for those challenged in that area it also becomes this like incredibly expensive emotionally and financially expensive battle

#Optimize #Fertility #Andrew #Huberman #Tim #Ferriss #Show

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30 Comments
  1. Brought to you by Athletic Greens’s AG1 all-in-one nutritional supplement http://athleticgreens.com/tim, Eight Sleep’s Pod Cover sleeping solution for dynamic cooling and heating http://eightsleep.com/Tim, and Protekt’s REST sleep supplement https://protekt.com/tim

  2. Don’t do IVF! Find a great non-hospital fertility specialist (Like Dr Nicole Morris, whom we are using) and spend WAY less money, have WAY better chances and get healthier to boot.

  3. The matter is complex: a cascade rather than a to b: The best way is just exercise and diet to strengthen your organs and buffer or maintain a papper PH…..Extrapolate! 🤖🤖😉😉🧬🧬👁👁🪄🪄🙍‍♂🙍‍♂🎶🎶👍👍💪💪🤖🤖⚡⚡

  4. What if… I cold plunge after using sauna. Has this been scientifically researched? Can this be a potential solution?

  5. how is a phone affecting this? isnt a campfire or heating a higher temperature?

  6. When the next 4-hour body ????

  7. Nathan aprovou este vídeo

  8. hamza creaming himself after hearing 4:45 onwards

  9. The pink elephant in the room regarding ASD in kids: prenatal ultrasounds.

  10. Does alopecia affect fertility in men ?

  11. This should have millions of views! This affects all of us! 💔
    Do not give up. Keep learning and protect yourself! ❤ You will be the educator one day.

  12. I TOOK OP N NG , THEY R UNDER MY ROOF

  13. Dr. Huberman didn’t mention the actual potential causes of the fertility crisis. The factors he did mention cannot be the primary cause of this issue. Sperm counts and total birth rates have been declining since at least 1972 according to the published data. Since then many have quit smoking but the fertility rate continues to decline. Cell phones weren’t even invented in the 1970s. Thus, neither smoking nor cell phone exposure can be the cause. Why didn’t the Dr. discuss about studies showing persistent organic pollutants and heavy metals in sperm, menses, and follicular fluid? Our exposure to these compounds, as well as other xenoestrogens such as phthalate and bisphenols, at least correlates with the fertility data. Further, there are studies correlating sperm abnormalities with these exposures. In my opinion, this superficial analysis, and instructions to simply take some supplements, misses the mark completely on this topic.

  14. Me and my wife r trying to concieve, she has gotten pregnant various times but after a few weeks it never continues, the last part couldnt have been more accurate, it is very much a very emotional / expensive mental battle with life itself .

  15. Yep, no matter if you’ve been called infertile or whatever, after reading Dobbie Nerkstrol's guide, I ended up pleasantly surprised. Within 60 days anyone can get pregnant, feeling the changes in your body the first few weeks. After go’ogling her I understood it's not a miracle kind of thing like the title suggests, but you can bet you'll boost your chances.

  16. I took my phone out of my pocket and felt better the same week. Began having involuntary erections again, and wasn't so down all the time.

  17. If I turn on iphone on airplane mode and put it in my pocket is that still bad?

  18. 10:07 when they say alcohole wount affect the child

  19. came from hamza–quick question, i'll remove my phone from pocket, but what about airpods? is that an issue too?

  20. …. bro I don't need to optimize fertility. I'm already getting girls pregnant that are on birth control. Apparently birth control doesn't even work for Latina women and it's like documented and studies it's like 70 to 90% effective…. lol what? Apparently only works for like Asian girls and white girls…. geez

    I need some male birth control

  21. Blind spot: parenting lowers testosterone, general average health and happiness, looks, and wealth. Also there's opportunity costs for other good causes and goals.

  22. Disappointed in the EMF nonsense. Heat? Ok, it can be explained what the mechanism there might be. But no mechanism has ever been presented to explain how "EMF" (note that they never specify frequency) which is non-ionizing can affect any biological process much less sperm.

    Also, you are being bombarded with EMF in the TERAHERTZ right now! Is it affecting your sperm or anything else?

  23. Good on Huberman for atleast acknowledging the potential dangers of EMF

  24. It would be good to hear huberman to speak on varricoles.

  25. So it is the Covid 5G?

  26. So insightful. Thank you!

  27. Thanks for sharing this Tim. From someone who recently went through the stressful process of IVF I totally agree with every point mentioned in this chat. My wife and I tried for years and after following some strict “system” we conceived NATURALLY within 4 months.

    This is not a medical advice and you should talk to your doctor but here are some of the things I took and did for sperm quality, these were from the 4-hour body book and also as I worked closely with a specialist fertility nutritionist:

    – keep your phone away most of the time and if needed put it anywhere but not in your pocket (I took this advice from the 4-hour body book)
    – Avoid any food that is known to have been grown using pesticides, basically eat organic as much as possible
    – Main supplements I took were Vitmain D, Omega3, L-Carnitine, CoQ10, N-acetyl-cysteine (there are many more)
    – I monitored my sperm quality every month to adjust my system

    There is more your can do to optimise sperm/egg quality and I’m happy to chat to anyone who might need support or tips, my wife had a similar system with some adjustments to optimise female egg quality and would be happy to share that as well.

    All the best everyone

  28. First also interesting episode

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