Tools for Avoiding Heart Attack & Heart Disease | Dr. Peter Attia & Dr. Andrew Huberman

18 March 2025


Tools for Avoiding Heart Attack & Heart Disease | Dr. Peter Attia & Dr. Andrew Huberman



Dr. Peter Attia and Dr. Andrew Huberman discuss the surprising commonality of death as the first presentation of a heart attack, the evolution of cardiac life support, the importance of measuring ApoB levels early in life, and the critical role of managing blood pressure, exercise, nutrition, and sleep in preventing heart disease and kidney problems.

Dr. Peter Attia is the host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan and athletic performance. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast.

Watch the full episode: https://youtu.be/DTCmprPCDqc
Listen on Spotify, Apple Podcasts or other podcast platforms: https://go.hubermanlab.com/iX17ClYC
Show notes: https://hubermanlab.com/dr-peter-attia-exercise-nutrition-hormones-for-vitality-and-longevity

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When I was in medical school, and I think I even write about this in the book, we had a pathology lecture where the professor stands up there and he says, "What is the most common presentation "of a heart attack," and you know, us keener, first year med students hands shoot straight up, Chest pain. No, that's not the most common. Oh, shoulder pain radiating down the left arm. No. Nausea, shortness of breath. No, no, no. We rattled this off for a few minutes and he goes, "death." The single most common presentation for a myocardial infarction is death. Now, I would say today, that was 25 years ago. Today it's probably not the most common because advanced cardiac life support is so much better. But it's still strikingly common. Well, you could say that the best predictor of a heart attack is still a heart attack. This is just one of those things where we're going to spend a lot of time talking about things that feel good and feel bad when you change them, right? Like if you take a person who's not sleeping well, but who thinks they're sleeping well and you ask them for a leap of faith, which is, hey, gimme a month to help you sleep really well, yeah, you're going to feel better. You might not know it now because you don't know how bad you're sleeping. Now you've become acclimated to this. But this is not one of those domains, you know, exercise, nutrition, sleep, all those things. When you do those things better, you feel better. But you know, I don't want to overpromise on this. You're not going to feel better in the moment when you fix your lipids, but you'll feel better when you don't have a heart attack. So by all this logic, everybody should get their ApoB measured. How early in life should people do that? Starting in their twenties, in their thirties? Certainly if you have a family history that is of any concern, like if I could live my life over again, if I knew everything you know, then that I know today, yeah, I would've had mine measured in my twenties. You know, I didn't get my ApoB measured for the first time, probably till I was in my forties because, you know, well yeah, maybe late thirties, early forties, right? I had my first calcium scan when I was 35 and I had to beg, borrow, steal to get it done 'cause everyone was like why does a 35 year old want to do this? But I just felt something was wrong given my family history. And I'm glad I did. I'm glad I did that 'cause I learned something that completely changed the direction of my life. Okay, I know my ApoB numbers and that I might be that guy who's up in the you know, above 100 so I'm going to get this treated. That's a promise to myself. We covered the three major risk factors, which were blood pressure, keeping that in check, don't smoke, and ApoB. And we've now talked about the things to adjust ApoB levels. We did not really talk about things to adjust blood pressure. I'm assuming exercise sits as one of the foremost – Exercise, nutrition. Yeah, weight management is a huge one here. So you know, you take a person whose and this is one of those things where we don't immediately jump on the pharmacotherapy train with blood pressure because here there are side effects sometimes, and you do have to worry about overshooting. You don't really have to worry about overshooting a person's lipids. We do back off if we overshoot, but it doesn't cause a symptom. There's not a short-term immediate risk from doing that. If you overshoot somebody's blood pressure medication, you trade one problem for another problem. They become lightheaded when they get up to pee at night, they fall and bang their head. That's a devastating consequence. Totally unacceptable. So our goal is to see how much we can lower blood pressure without medication before we turn to medication. And let's be clear, the meds today are so much better than they used to be. Again, there was a day when the side effects of these medicines were miserable. That's simply not the case today. I mean ace inhibitors, angiotensin receptor blockers, I mean, these things are very well tolerated, especially the ARBs. So again, almost anybody can be on these things, but if we could get a person to lose 10 pounds and exercise every day, we see great effects with zone 2 stuff, right? So kind of the low intensity cardio. And your recommendation there, I know you talk about this in the book but I've thrown out numbers about 150 to 180 minutes per week. You go a bit higher. Yeah, we go 180 to 250, 240. Yeah, I'd like to see three to four hours a week of zone 2. So that's an important piece. And sleep is an important piece. So get the sleep right, get the exercise right. If you're over nourished, let's correct that problem. And if all of that doesn't work, and by the way that works a lot of the time. That works most of the time. If that doesn't work, then we've got pharmacotherapy. There is still a true phenomenon of essential hypertension, which is in individuals for whom all the fixable stuff has been fixed and they still have high blood pressure, we still have to medicate those folks. By the way, there's something that I want to mention here that doesn't get much attention but it's so important, which is the effect of high blood pressure on the kidney and also the brain itself. We've talked about the brain, we've talked about the heart, but the kidney doesn't get enough attention. The kidney is a remarkable organ. And I think if you're really in this game of trying to live longer, right? If you think, hey, you know, maybe we'll live 80, 85 years, but if we kind of start doing all of these other things and really optimizing our behaviors, that could be 95. Well, you have to start thinking about the capacity of the kidney. And once the glomerular filtration rate falls below a certain level, you have to be very careful with how you live your life. And unfortunately, this is one of those things that is another sort of mistake that's made in kind of modern medicine, which is we don't pay enough attention to how to measure kidney function correctly. We rely very heavily on something called creatinine as opposed to looking at another biomarker called Cystatin C which is far more accurate. And we also tolerate too low of a kidney function for a person's age. So we look at, you know, we might look at someone who's 50, who's kidney function is at 65% and say, you're totally fine. Because it's true that at 65% there is no problem. But you're not thinking, well, if this person has to live another 40 years and this continues to go down, they're going to potentially be staring down the barrel of needing dialysis the last five years of their life. Again, you want to die with compromised kidney function, but never from compromised kidney function. In fact, the hazard ratio of all cause mortality associated with compromised kidney function is even greater than that of heart disease. Once you cross that threshold, I mean lights out. once you are needing dialysis, I mean, your risk of death is higher than that of someone with high blood pressure, smoking. Even someone who has cancer, you have a higher risk of death having end stage renal disease than you do having cancer. So the kidney is so sensitive to blood pressure. This is a tiny organ that on every pump of your heart is getting 20% to 25% of your blood. Wow. So just imagine how sensitive and susceptible it is to elevated blood pressure. [Music Playing]

#Tools #Avoiding #Heart #Attack #Heart #Disease #Peter #Attia #Andrew #Huberman

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38 Comments
  1. Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against Suicidal, depression and anxiety. Saved my life.

  2. Choose ur partners wisely so your kids don’t have to suffer from these issues…

  3. Oh sleep well and exercise. Haven't heard that before

  4. Drink more water
    Walk
    Eat garlic
    Add cayenne pepper to your meal.
    Try reducing stress.

  5. So apparently this guy Huberman was also a fraudulent person, a grifter. David Sinclair was also a grifter and a fraud.. no matter where you look for advise, beware of smart people who says stuff you like to hear

  6. 100% of people that adopt a whole food plant based diet go to a normal Blood pressure. Even if they're still obese. I'm 270lbs and my bp is 112/64

  7. Hiw do you get plaque out of your arteries?

  8. I got my BYOB measurements and I was over shooting.

  9. So tired of everyone thinking they have the answer. They spend their whole lives worrying about and trying to prevent death that they forget to actually live. When your time is up it’s up. All up to God. Do the best you can & let the chips fall where they may.

  10. Are betablockers bad for say a 40 year old? I talked to my doctor about ARBs, but he said betablockers are fine.

  11. We talk about extending our life 5-10 years but have we considered whether or not we want to live those extra years? I've seen plenty of people in that age range and I'm not sure I want to live in that age range for that long. As I age I am now more concerned with being able to shut off the light switch quicker than with extending the dimming so to speak.

  12. Grief and heartbreak must be dealt with first.

  13. I’m just curious,Dr Peter, weren’t you recommending everyone to get the jabs? More males are having heart issues? Maybe we all missed it but you ever state you might’ve made a mistake ?recommending those? The evidence is overwhelming.

  14. It’s really interesting what he has mentioned in clinical practice. Most of the patients who we see with End Stage Renal Disease eventually die suddenly.

  15. It's really hard to hit those numbers, especially if you're weight training and working a full time job.

  16. To avoid heart attack don’t get the jab

  17. Find out where on earth heart attacks are the rarest, probably the blue zones? And compare our diet to there’s and you’ll find your answer.

  18. No heart attack but needed a triple bypass feeling alot better now .

  19. I have a good diet, don’t smoke, don’t drink, exercise almost every day and I still had high blood pressure. I watched Gary Brecka explain the supplement TMG and how it could lower idiopathic blood pressure and in a week my blood pressure went from 140s over 90s to 120s over 80s. So long story short, try TMG before getting on medication!

  20. Lets die peacefully eventually ….instead of watching these stuff makas people panic and sickeness of afraid to being sick…😂

  21. I always find it a little comical we are getting longevity advice from middle aged men.

  22. 05:55 kidney function and metrics.

  23. I have tons of patients on dialysis, and it is truly horrible to depend on dialysis to survive

  24. I tried everything for my bp. Weight ,cardio everything pills fixed it no side effects. I work 6 or 7 days a week! That might have somthing to do with it.

  25. Great video and very helpful and agree medications are last resort
    The traditional blood pressure monitors are now pretty much obsolete as they dont give a full arterial reading and thus prescriptions are hit and miss when used by a doctor.
    There is a new product called the Sphygmor technology traditionally only used in hospitals and cardiologists called the Conneqt pulse.FDA approved/ medical grade .
    Pretty much a personalized, arterial health ecosystem at your fingertips.
    Traditional BPM only measure systolic and diastolic as well as heart rate.
    Measurements with this new device include central blood pressure, augmentation pressure , central pulse pressure, brachial blood pressure and also subendocardio measurements gives a more accurate reading. The traditional doctors are still using 100 year old technology that has been superseded.

  26. 6:30 Having been through some life altering health issues and seeing the medical system from the inside more than I would like. I want to say "no one" but certainly "almost no one" (hospital professionals) has the capacity or the man power to take individual patients and say " you are ok now but…" they are way too over worked and under staffed to be able to have that bandwidth. in my opinion they would at best say " go see so and so" and they can help you live a better, longer life.

  27. . "I love how informative this video is! And if you’re interested in boosting your health naturally, try **Planet Ayurveda Arjun Tea**. It’s packed with benefits for your heart and overall health!"

  28. What is in that mason jar?

  29. How come and they don’t know

  30. came here looking for advice on heart health and I got "dont smoke, excrecise and diet". Kinda expected more from Huberman.

  31. Cystatin C isn't available anywhere except for research settings.

  32. Stress is literally killing me. I’m 65 and go way harder than most women my age. I’m a preschool teacher for 10 years now so I’m dealing with 3, 4 and five—year-olds that come from dysfunctional homes. And then I am building a house with a partner that tends to have an anger problem. I went to have a wellness check and found out my blood pressure was 180/95 I about freaked. I can’t cut out the job and I can’t just drop this house so I Went on blood pressure medicine until I could get this all ironed out. I Do not smoke, and I’m not overweight. But I think this is been going on a long time, and I didn’t even know it. Particularly the sleep problem in an essence never being able to recover from the daily stressors and weekend stressors of my life I don’t know how to get off this, Merry go round.

  33. Slimming is not good for this because it narrows the veins and arteries I could be wrong this is an idea

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